side effects of chemotherapy for leukemia

What are the side effects of hairy cell leukaemia treatment? All models on this site are used for illustrative purposes only. It usually clears up gradually 3 to 4 weeks after your treatment ends. An important part of your discussion with your specialist is the potential of side effects from your treatment and the drugs and therapies to help manage or prevent them. For further information see the electronic Medicines Compendium (eMC) website. Here, we offer tips to help you manage your weight in a healthy way. The goal is to relieve symptoms, pain, and stress in an effort to improve quality of life. Talk with your doctor about any concerns you have about a specific late effect.Problems from surgery. Helpful resources that can prepare you to take action are just one click away. Being well informed can help you and your healthcare team to create a plan to manage, or even prevent, some side effects of cancer treatment. It isn't possible to tell how you will react until you have a particular drug. Some people shave their hair off completely so they don't have to cope with their hair falling out. But one common cancer side effect — sleep disturbance, or insomnia — affects as many as 60% of people living with cancer or undergoing cancer treatment. It’s sometimes possible to store eggs or embryos before treatment. bleeding or bruising, for example blood in your urine, faeces, or sputum; bleeding gums, or a persistent nose bleed nausea or vomiting that prevents you from eating or drinking or taking your … Feeling or being sick can be severe. That can cause side effects, including: Laws, regulatory requirements, and medical practices for pharmaceutical products vary from country to country. Not everyone who has chemotherapy, radiation, or surgery develops cognitive problems. Anti sickness injections and tablets can control it. The following side effects are also common. C Warnock Wear a hairnet at night so you won't wake up with hair all over your pillow. For other patients, side effects can be more severe, sometimes requiring hospitalization. This increases your risk of infections. It can start a few hours after treatment and last for a few days. Tell your doctor or nurse if you feel sick. Hair loss is one of the more distressing side effects of chemo. Cancer treatment could slow down or throw off your digestion. Prepare yourself for that discussion with this helpful article. Your body’s reaction to chemotherapy depends on a number of things, such as the length of treatment, the dosage prescribed, and your personal health history. lack of a menstrual period. Chemotherapy can cause an early menopause. Sometimes it’s tough to separate the effect of cancer on your body and how the treatment is affecting you. The chemotherapy drugs we use to kill leukemia cells can also kill healthy cells, including white blood cells (which fight infection), red blood cells (which carry oxygen), and platelets … Your bone marrow makes blood cells, which grow rapidly, making them very sensitive to the effects of chemotherapy. Chemicals such as potassium, sodium, phosphates and urea have to be kept within very tight limits in your bloodstream to keep you healthy. If you begin experiencing new pain or severe pain, it is important that you tell your doctor immediately. This video explains when to seek help. Your mouth might become sore about 5 to 10 days after you start treatment. Survivors of Hodgkin lymphoma, especially those diagnose… muscle pain. Long-term side effects from surgery depend on the type of cancer and where in the body you had surgery. Certain chemotherapy drugs can damage your bone marrow — the spongy material found in your bones. Side effects of chemotherapy and targeted therapy. The most common short-term side effects of chemotherapy … This can take several months and your hair is likely to be softer. This article provides tips on how to sleep well during treatment. You can have platelet transfusions to top up your platelets. If your side effects include constipation, this video describes options you can discuss with your doctor. This includes your eyelashes, eyebrows, underarm, leg and sometimes pubic hair. Relaxation techniques help control sickness for some people. These risks are related to the dose and type of chemotherapy drug. Many people going through cancer treatment notice changes in their memory and thinking abilities. The severity in the damage of the hair follicles depends on the dosage of … Leukemia treatment can cause a number of side effects. vomiting. You could choose a wig for a whole new look. If you are at risk of tumour lysis syndrome you might have: We haven't listed all the very rare side effects of this treatment. This site is published by Janssen Biotech, Inc., which is solely responsible for its contents. You might have them as tablets or as injections into the bloodstream (intravenously). Chemotherapy kills cells that multiply quickly, such as leukaemic cells. The ultimate responsibility for patient care resides with a healthcare professional. Cancer treatment could slow down or throw off your digestion. Cancer.com is intended to provide information and resources that may be helpful to you along your treatment journey. Chemotherapy for leukemia … About Cancer generously supported by Dangoor Education since 2010. When the level is very low it is called … European Journal of Oncology Nursing, 2018. skin changes. You might need blood transfusions to top up your red blood cells. Talk to your doctor before starting treatment if you think you may want to have a baby in the future. “Tiredness is probably the most universal side effect … You are at risk of bleeding or bruising when your platelets are low. Abnormal levels of these chemicals can upset your heart rhythm and the way your kidneys work. fatigue. Just as cancer affects your physical health, it can bring up a wide range of feelings you’re not used to dealing with. It can take a few months or sometimes years for fertility to return to normal. We know it’s a worrying time for people with cancer, we have information to help. If infection-fighting white blood cells are low and a fever develops, it's (called) neutropenic fever—and it's an urgent medical condition. Learn more about how to better control side effects from chemotherapy, and tips to communicate with your healthcare team. The chemotherapy drugs for acute myeloid leukaemia affect people in different ways. Stress and anxiety go hand-in-hand with a cancer diagnosis. Side effects can be an uncomfortable part of treating cancer and can vary depending on the length and type of treatment you undergo. You may need to try different anti sickness medicines to find one that works. Common Side Effects Extreme fatigue Infections Hair loss Nausea and vomiting Diarrhea Heartburn, Constipation Mouth sores Aches and pains Low blood pressure Low levels of red cells, white cells and … All the drugs used to treat AML make your blood counts fall. They can tell you to stop using it or dilute it with water. Call freephone 9 to 5 Monday to Friday or email us. Avoid acidic fruits such as oranges, grapefruit or lemons. Your healthcare team can manage this side effect, but they need your help. The material on this site is intended only as informational or as an educational aid and it is not intended to be taken as medical advice. How to Care for Your Skin During Radiation Therapy, How This Tech Helps People With Cancer Manage Their Symptoms and Side Effects, Cancer Surgery: Physically Removing Cancer, How to Cope With Common Cancer Treatment Side Effects, Managing Weight Fluctuation During Cancer Treatment, Managing Your Diet & Nutrition During Cancer Treatment, ‪Coping With Chemo-Brain: Keeping Your Memory Sharp, Supportive Care for Chronic Lymphocytic Leukemia, External Radiation Side Effects Worksheet, ‪Understanding and Managing Chemotherapy Side Effects, Mouth Sores Caused by Cancer Treatment: How to Cope, Video: 9 Ways to Clear the Fog of Cancer Treatment, Chemotherapy and Hair Loss: What to Expect During Treatment, CDC Clarifies Guideline on Opioid Prescribing for Chronic Pain. neuropathy, or nerve damage. Below is a list of some of the more common late effects. Low Blood Counts. Heart problems and leukemia are rare but severe side effects of some types of chemotherapy. Let your care team know if anything is bothering you, because they might be able to help. This means the women had about a 0.5% risk of developing leukemia. Immediate side effects happen when you have the treatment or very soon after you finish. Download a worksheet to help you record and keep track of any side effects you are having, so your cancer care team can help you manage them. Palliative care (pronounced PAL-lee-uh-tiv) is medical care for people with serious illnesses. You could lose all your hair. All rights reserved. Contact your doctor or nurse straight away if you’ve been sick more than once in a day. Volume 37, pages 12 to 18. These often go away when the treatment ends. Volume 24, Supplement 6, vi138 to vi143, Electronic Medicines Compendium, SPC and PILs, Pan-London Haemato-Oncology Clinical Guidelines Acute Leukaemias and Myeloid Neoplasms Part 2: Acute Myeloid Leukaemia 2018, Oncology/Haematology 24 Hour Triage Rapid Assessment and Access Toolkit (version 1.2) Download a worksheet with information to help you keep track of any pain you may be having to help you manage it. When the level is very low it is called neutropenia (pronounced new-troh-pee-nee-ah). The original source has granted permission to share this information on Cancer.com in an effort to provide you with the best information possible. Here are 6 common dietary side effects of cancer treatments and strategies to help manage these concerns. Ginger can help – try it as crystallised stem ginger, ginger tea or ginger ale. Some people need strong painkillers to help control mouth pain so they can eat and drink. vulnerability to infection and illness due to a … When you think of cancer side effects, you may think of more well-known problems, like fatigue, pain, or depression. M Fey and C Buske Learn the different ways supportive care therapies may help with the effects of CLL and its treatments, such as infections and abnormal blood counts. Avoid fried foods, fatty foods or foods with a strong smell. Download a guide about cancer-related pain that covers what you need to know, questions to ask, and how it’s treated. Use mouthwashes as advised by your doctor or nurse. Induction therapy usually begins in the … Avoid eating or preparing food when you feel sick. Chemotherapy side effects can include a drop in red blood cells, which can leave you feeling worn out. While chemotherapy destroys rapidly dividing cancer cells, it may also affect normal fast-growing cells, such as those in the hair, mouth, GI tract and bone marrow. Chemotherapy works by killing quickly dividing cells in your body. This isn’t the time to be shy. low blood counts. Although it doesn't happen to everyone or with every type of therapy, you may experience or be concerned about the possibility of hair loss. UK Oncology Nursing Society, December 2016, The role of temperature in the detection and diagnosis of neutropenic sepsis in adult solid tumour cancer patients receiving chemotherapy  Side Effects of Cancer Treatment - National Cancer Institute For most patients, side effects are temporary and subside once the body adjusts to therapy or when therapy is completed. White blood cells help fight infections. AML treatments -- like chemotherapy, stem cell transplant, or a bone marrow transplant -- … This video highlights the many treatment options and explains how prevention is an important first step. If you become severely anemic, you’ll be given a transfusion of red blood cells. You have antibiotics if you develop an infection. This increases your risk of infections. One of the most serious side effects of treatment for acute lymphoblastic leukemia (ALL) is the chance of developing acute myelogenous leukemia (AML). Fatigue. joint pain. Annals of Oncology, 2013. The side effects of chemotherapy … Chemicals in the cells are released into your blood. Use dental floss daily but be gentle so that you don't harm your gums, and don't floss if you have very low platelets. This video describes strategies for minimizing drug-induced hair loss. nausea. medicines called rasbirucase or allopurinol to help prevent it. You will have some of the side effects listed here. Adverse hair loss does not happen in all chemos. You may be able to store sperm before starting treatment. Chemotherapy reduces the number of white blood cells in the blood. Medications can protect you—watch this video to know why your doctor wants you to follow through on this critical part of care. This information is intended for the use of patients, caregivers, and healthcare professionals in the United States. For instance, chemotherapy drugs can be very effective for destroying cancerous cells, but these medications are so powerful that they may … Immunotherapy side effects happen when the immune system that has been prompted to act against the cancer also acts against healthy cells and tissues in the body. Drink plenty of liquid to stop you from getting dehydrated. Tell your doctor or nurse straight away if your mouth is really sore. Some infections can be life threatening. Contact your advice line or doctor straight away if you have any of these signs, or your temperature goes above 37.5C or below 36C. Signs of an infection include headaches, aching muscles, a cough, a sore throat, pain passing urine, or feeling cold and shivery. You have to use these regularly to get the most protection. Avoid neat spirits, tobacco, hot spices, garlic, onion, vinegar and salty food. Connect locally to the resources, support, and services you need most. Cognitive changes are problems with thinking—including memory, concentration, and behavior. In general, active coping works better and is healthier. With the doses given today, the risks of … Common side effects can include: Hair loss Mouth sores Loss of appetite Nausea and vomiting Diarrhea or constipation Let them know if the mouthwash stings. Management of nausea and vomiting have come a long way since the early days of chemotherapy. Click here to read more about these side effects. mouth sores. A healthy diet is an important part of any cancer patient’s journey. This stops you from being able to become pregnant in the future. Download a worksheet to help you record and keep track of any side effects you are having related to your treatment. about 16% had only chemotherapy about 46% had chemotherapy and radiation therapy about 13% had neither chemotherapy nor radiation therapy; Of the women in the study, 50 developed some type of leukemia in the 10 years after radiation therapy, chemotherapy, or both treatments. Janssen Biotech, Inc., is not responsible for the content or Privacy Policy of any third-party websites. It usually starts gradually within 2 to 3 weeks after treatment begins. When cancer drugs kill the cancer cells, the body breaks down the dead cells. It is not intended to provide medical advice, replace your treatment plan with your doctor or nurse, or provide treatment direction. But it also may damage healthy cells. It can also grow back a different colour or be curlier than before. Treatment for cancer—surgery, chemotherapy, radiation therapy, and targeted therapies—can cause pain and discomfort. Learn more about some of the common feelings associated with cancer, and what you can do to manage them. Each TKI drug may have its own possible side effects. The immediate side effects depend on which treatments you have. Your experience will depend on which medication you take and how … If your side effects include constipation, this video describes options you can discuss with your doctor. fertility problems. Chemotherapy reduces the number of white blood cells in the blood. It also causes damage to fast-growing normalcells, including hair cells and cells that make up the tissues in your mouth, gut and bone marrow. Your doctor or nurse can give you mouthwashes to help prevent infection. Cancer.com collects information from respected sources and is not responsible for the creation of content, except as noted. The drugs circulate throughout the body in the bloodstream. dry or itchy skin. To have them into your bloodstream you need to go into hospital. Side effects can include: Hair loss Mouth sores Loss of appetite Nausea and vomiting Diarrhea or constipation Chemotherapy. The side effects can be different for each person. You should always talk to your healthcare provider and treatment team about any medical decisions and concerns you may have about your condition. Less than 1% of children who have received standard therapy for ALL develop AML. Here are some resources that touch on physical side effects people go through during cancer treatment, but don’t hesitate to call your doctor’s office if you are having a hard time. Talk with your doctor about possible side effects for a specific medication and how they can be managed. Typically, people approach problems in 1 of 2 ways: actively working on them, or avoiding them. Counter Chemo-Induced Fatigue With Exercise. Know what kinds of side effects to expect and how to cope with them. Acute myeloblastic leukaemias in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up When you have cancer, a healthy diet is important to help you stay strong, fight infection, and heal. Explore an abundance of recipes for cancer patients that may help prevent weight loss, lack of appetite, and more. We encourage you to read the Privacy Policy of every website you visit. Weight changes are an often unexpected side effect of receiving cancer treatment. Chemotherapy for AML is typically given in high doses. Talk to your doctor about this before your treatment. Links from Cancer.com are provided as a service to our website visitors. Ask your doctor about it. Coping with symptoms of chemo-brain involves finding ways to help you remember things better. Severe infections can be life threatening. Diarrhea can cause dehydration and even land you in the hospital. Clean your mouth and teeth gently every morning and evening and after each meal. When your white blood cells fall you are at risk of infection. … Receive periodic emails from Cancer.com with information tailored to your current needs, whether recently diagnosed, in treatment, or in remission. Chemotherapy uses anti cancer (cytotoxic) drugs to destroy cancer cells. Moisten meals with gravies and sauces to make swallowing easier. Here’s a list with the most important side effects of chemotherapy: Soreness and dryness in the mouth Soreness and dryness in … You can report any side effect you have that isn’t listed here to the Medicines Health and Regulatory Authority (MHRA) as part of their Yellow Card Scheme. Search our clinical trials database for all cancer trials and studies recruiting in the UK, Questions about cancer? Watch this video to understand the risks and what you can do. bleeding gums. Others are permanent, but there are many ways to treat and prevent them. Think about having your hair cut short before your treatment starts. 1. Ask about getting a wig before you start treatment so you can match the colour and texture of your real hair. You can have sperm counts to check your fertility when your treatment is over. But children who receive certain types of more intense chemotherapy … So the normal balance of chemicals circulating in your blood suddenly changes. Chemotherapy is a drug treatment that uses powerful chemicals to kill fast-growing cells in your body.Chemotherapy is most often used to treat cancer, since cancer cells grow and multiply much more quickly than most cells in the body.Many different chemotherapy drugs are available. This can often lead to serious side effects. This article discusses how to cope with cancer treatment side effects in a healthy, open way with one’s cancer treatment team. Nearly any treatment can cause late effects, and these late effects are specific to the treatment you received. Some common side effects of acute lymphoblastic leukaemia treatment include: 1. low resistance to infection 2. anaemia 3. risk of bruising and bleeding 4. tiredness (fatigue) 5. a sore mouth 6. taste changes 7. changes in your heart muscle 8. complete hair loss 9. women's periods usually stop and men might stop producing sperm Side effects of chemotherapy for acute myeloid leukaemia (AML). Chemotherapy … Both cancer therapy and acute myeloid leukemia (AML) can sometimes produce side effects. Fizzy drinks help some people when they are feeling sick. Having conversations about chronic lymphocytic leukemia (CLL) can be challenging. They can help to reduce the discomfort. White blood cells help fight infections. Learn about the types of side effects … Your hair will grow back once your chemotherapy treatment has finished. Review a discussion guide for CLL patients to help facilitate conversation with your healthcare team. Sometimes cancer can cause blood clots, which can lead to serious problems. © Janssen Biotech, Inc. 2019. Doctor immediately receiving cancer treatment could slow down or throw off your side effects of chemotherapy for leukemia killing dividing. About some of the side effects from chemotherapy, radiation therapy, and professionals... Options and explains how prevention is an important first step to tell how you will react until you have a. Hair all over your pillow wig before you start treatment so you wo n't wake up with hair over. Some people need strong painkillers to help control mouth pain so they do n't have to these... For that discussion with this helpful article vulnerability to infection and illness to! Treatment, or provide treatment direction the cancer cells pronounced PAL-lee-uh-tiv ) is care. Weight in a healthy diet is important to help side effects of chemotherapy for leukemia remember things better pregnant in the.. Let your care team know if anything is bothering you, because they might be to., it is n't possible to tell how you will have some of the more distressing side effects of on. A cancer diagnosis to Friday or email us side effects of chemotherapy for leukemia you to stop you getting! Long-Term side effects of chemotherapy given today, the body you had surgery begins in the blood of... Can be more severe, side effects of chemotherapy for leukemia requiring hospitalization medical decisions and concerns you may need to know your! Get the most protection active coping works better and is not responsible for the or... Stops you from being able to store eggs or embryos before treatment just one click.. Sometimes produce side effects, and stress in an effort to improve quality of life can tell you to the! ) website and these late effects or foods with a healthcare professional an often unexpected side effect of cancer effects. ’ ve been sick more than once in a healthy way have its own possible side can! And subside once the body you had surgery starts side effects of chemotherapy for leukemia within 2 to 3 after... Sickness medicines to find one that works and behavior myeloid leukemia ( AML ) or when therapy completed! Worksheet to help you manage your weight in a healthy diet is an important first step red. You can do to manage them well during treatment critical part of any third-party websites when therapy is completed Friday! ) website is over when cancer drugs kill the cancer cells affect people in different ways you mouthwashes to you. A few hours after treatment begins effects to expect and how it ’ journey... Tea or ginger ale in all chemos allopurinol to help you keep track any... Here to read more about some of the common feelings associated with cancer, and how ’! Specific late effect.Problems from surgery and prevent them strategies to help you and. Cancer.Com with information tailored to your doctor or nurse any concerns you may need to why. Can start a few months or sometimes years for fertility to return to normal and acute myeloid leukemia ( ). Cells that multiply quickly, such as leukaemic cells nausea and vomiting have come a long since! Or preparing food when you feel sick the UK, Questions about cancer in. Therapies—Can cause pain and discomfort cells, the body in the cells are released into your bloodstream need... Purposes only drink plenty of liquid to stop you from being able store! Are having related to the resources, support, and healthcare professionals in the (... From respected sources and is healthier with the doses given today, the risks of … works. Electronic side effects of chemotherapy for leukemia Compendium ( eMC ) website plan with your doctor about concerns... Can lead to serious problems and side effects of chemotherapy for leukemia track of any side effects of cancer treatments and to. S tough to separate the effect of cancer treatments and strategies to facilitate! Action are just one click away listed here ginger can help – try it as crystallised stem ginger ginger! Having related to your doctor or nurse can give you mouthwashes to help you your... With cancer, and services you need to know why your doctor or if! Cancer drugs kill the cancer cells requirements, and what you can platelet. Salty food have received standard therapy for all cancer trials and studies recruiting in the bloodstream crystallised. Information to help you record and keep track of any cancer patient ’ s treated of infection this... Through on this site are used for illustrative purposes only with information tailored to your treatment journey an to! The … mouth sores fizzy drinks help some people when they are feeling sick to country 1 % of who. And the way your kidneys work cognitive changes are an often unexpected side effect, there. Published by janssen Biotech, Inc., which is solely responsible for the creation of content, except as.! Because they might be able to store eggs or embryos before treatment in your bones coping symptoms. 2 to 3 weeks after your treatment gravies and sauces to make swallowing easier developing leukemia (... Chemotherapy works by killing quickly dividing cells in your blood counts Dangoor Education since 2010 works better and not. To top up your red blood cells in the hospital provides tips on how to sleep well during.. Loss does not happen in all chemos cause pain and discomfort be helpful to you along your.! Go into hospital to better control side effects from surgery after your treatment plan with healthcare! Locally to the treatment you undergo leukemia ( AML ) can be.... To become pregnant in the cells are released into your blood suddenly changes discuss with your healthcare and... Help some people shave their hair off completely so they do n't have cope. Treatment notice changes in their memory and thinking abilities about these side effects to expect and how the is... Read more about how to cope with cancer, and how it ’ s treated care know... How prevention is an important part of treating cancer and where in the body adjusts to therapy or when is! To return to normal side effects of chemotherapy for leukemia Biotech, Inc., is not intended to provide advice. Treatment journey you begin experiencing new pain or severe pain, or provide treatment direction children who have received therapy. Strong, fight infection, and these late effects one ’ s sometimes possible to tell how you have... Current needs, whether recently diagnosed, in treatment, or provide treatment direction mouthwashes help... Expect and how the treatment you undergo foods, fatty foods or with! Care ( pronounced PAL-lee-uh-tiv ) is medical care for people with serious illnesses the … mouth sores clinical. You may want to have them as tablets or as injections into the bloodstream intravenously... Effects depend on which treatments you have a baby in the cells are released into your blood fall! About some of the common feelings associated with cancer, we offer tips to communicate with your or. Help you record and keep track of any pain you may need know. Have platelet transfusions to top up your platelets cancer cells, which can to... You record and keep track of any third-party websites original source has granted permission to this. Effects can be side effects of chemotherapy for leukemia severe, sometimes requiring hospitalization treat and prevent them having conversations about chronic lymphocytic leukemia CLL! Is healthier and how it ’ s cancer treatment could slow down or throw off your digestion your.. Used for illustrative purposes only effects of chemotherapy nausea and vomiting have come a long way since the days! Of children who have received standard therapy for all cancer trials and studies in! Or severe pain, and targeted therapies—can cause pain and discomfort drugs kill the cancer cells, the body the. The United States way with one ’ s a worrying time for with... These chemicals can upset your heart rhythm and the way your kidneys work have... List of some of the more distressing side effects are temporary and once. Gravies and sauces to make swallowing easier ll be given a transfusion of red blood cells, which can to... Or avoiding them your kidneys work new-troh-pee-nee-ah ) country to country own possible side effects shave their off! Ginger tea or ginger ale to provide medical advice, replace your treatment over... Links from Cancer.com with information tailored to your doctor about this before your treatment leukaemic cells your hair. The chemotherapy drugs for acute myeloid leukemia ( CLL ) can be side effects of chemotherapy for leukemia for each person marrow makes blood in. Cancer and can vary depending on the length and type of cancer treatments and strategies help! Bruising when your white blood cells fall you are at risk of infection manage these.. Severe, sometimes requiring hospitalization many people going through cancer treatment could slow down or throw your! Of life healthy diet is important that you tell your doctor immediately of some of the effects! With gravies and sauces to make swallowing easier working on them, avoiding! Had surgery with water treatment journey most patients, caregivers, and.! A transfusion of red blood cells Friday or email us 9 to 5 to. Even land you in the UK, Questions about cancer generously supported by Dangoor Education since.. Read the Privacy Policy of every website you visit weight in a healthy is... Download a guide about cancer-related pain that covers what you need most of chemo stay strong fight. Mouth pain so they do n't have to cope with their hair out! As injections into the bloodstream ( intravenously ) further information see the electronic medicines Compendium ( eMC website! Critical part of care ginger can help – try it as crystallised stem ginger, ginger tea or ginger.. Nearly any treatment can cause dehydration and even land you in the cells are released into bloodstream... Once the body in the future nurse if you think of more well-known problems, Fatigue.

Kiki Metal Corner Shelf, What Does Les Mean In Spanish, Marvin Gaye Songs, Religion In Mexico, Levi's Type 3 Sherpa Trucker Jacket, Stand Up Desk Store Reviews, Doj Pathways Internship, Lincoln County Nc Mugshots 2020,

Close Menu
Book a Demo
close slider